Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys

Abstract

Chronic cocaine exposure has been associated with progressive brain structural and functional changes. Clarifying mechanisms underlying cocaine's progressive brain effects may help in the development of effective cocaine abuse treatments. We used a controlled squirrel monkey model of chronic cocaine exposure (45 mg/kg/week for 9 months) combined with ultra… (More)
DOI: 10.1007/s00213-011-2292-6

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