Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus.

@article{DomnguezEscrib2006ChronicCE,
  title={Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus.},
  author={Laura Dom{\'i}nguez-Escrib{\'a} and Vicente Hern{\'a}ndez-Rabaza and Mario Soriano-Navarro and J. A. Barcia and Francisco Javier Romero and Jose Manuel Garc{\'i}a-Verdugo and Juan Jose Canales},
  journal={The European journal of neuroscience},
  year={2006},
  volume={24 2},
  pages={586-94}
}
Recent observations indicate that drugs of abuse, including alcohol and opiates, impair adult neurogenesis in the hippocampus. We have studied in rats the impact of cocaine treatment (20 mg/kg, daily, i.p.) on cell proliferation, survival and maturation following short-term (8-day) and long-term (24-day) exposure. Using 5'-bromo-2-deoxyuridine (BrdU) and Ki-67 as mitotic markers at the end of the drug treatments, we found that both short- and long-term cocaine exposures significantly reduced… CONTINUE READING
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