Chronic cocaine alters brain mu opioid receptors

@article{Unterwald1992ChronicCA,
  title={Chronic cocaine alters brain mu opioid receptors},
  author={Ellen M. Unterwald and Jennifer Horne-King and Mary Jeanne Jeanne Kreek},
  journal={Brain Research},
  year={1992},
  volume={584},
  pages={314-318}
}
The possibility that dopamine may modulate the expression of opioid receptors was investigated by determining the effects of chronic cocaine administration on the density of mu opioid receptors. Quantitative in vitro autoradiography with the highly selective mu opioid ligand [3H]DAMGO was used to measure and localize changes in mu opioid receptors in the brains of rats administered cocaine or saline three times daily for 14 days. Significant increases in [3H]DAMGO binding were measured in areas… CONTINUE READING
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