Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability.

@article{Modi2013ChronicCR,
  title={Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability.},
  author={Hiren R Modi and Ameer Y Taha and Hyungwook Kim and Lisa Chang and Stanley I. Rapoport and Yewon Cheon},
  journal={Journal of neurochemistry},
  year={2013},
  volume={124 3},
  pages={376-87}
}
Chronic administration of mood stabilizers to rats down-regulates the brain arachidonic acid (AA) cascade. This down-regulation may explain their efficacy against bipolar disorder (BD), in which brain AA cascade markers are elevated. The atypical antipsychotics, olanzapine (OLZ) and clozapine (CLZ), also act against BD. When given to rats, both reduce brain cyclooxygenase activity and prostaglandin E(2) concentration; OLZ also reduces rat plasma unesterified and esterified AA concentrations… CONTINUE READING