Chronic clonazepam administration induced benzodiazepine receptor subsensitivity

@article{Crawley1982ChronicCA,
  title={Chronic clonazepam administration induced benzodiazepine receptor subsensitivity},
  author={J. Crawley and P. Marangos and J. Stivers and F. Goodwin},
  journal={Neuropharmacology},
  year={1982},
  volume={21},
  pages={85-89}
}
Clonazepam and chlordiazepoxide were administered chronically in increasing doses for three weeks in two different strains of mice. Forebrain [3H]diazepam binding was assayed in groups of mice sacrificed at 2, 26, 50 hr and 10 days following the last dose. Scatchard and single point analyses revealed a significant decrease in the number of [3H]diazepam binding sites [Bmax] which persisted for at least two days following chronic clonazepam treatment. The Bmax changes observed following… Expand
92 Citations
Chronic benzodiazepine treatment increases [3H]muscimol binding in mouse brain
  • 42
Time course for development of benzodiazepine tolerance and physical dependence
  • 85
Tolerance to the anticonvulsant effect of clonazepam in mice: no concurrent change in plasma concentration
  • 21
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Pharmacological characterization of benzodiazepine receptors in the brain.
  • 268
Putative endogenous ligands for the benzodiazepine receptor.
  • 82
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
  • 1,162
Benzodiazepine receptors in rat brain
  • 1,370
...
1
2
...