Chronic clonazepam administration induced benzodiazepine receptor subsensitivity

@article{Crawley1982ChronicCA,
  title={Chronic clonazepam administration induced benzodiazepine receptor subsensitivity},
  author={J. Crawley and P. Marangos and J. Stivers and F. Goodwin},
  journal={Neuropharmacology},
  year={1982},
  volume={21},
  pages={85-89}
}
Clonazepam and chlordiazepoxide were administered chronically in increasing doses for three weeks in two different strains of mice. Forebrain [3H]diazepam binding was assayed in groups of mice sacrificed at 2, 26, 50 hr and 10 days following the last dose. Scatchard and single point analyses revealed a significant decrease in the number of [3H]diazepam binding sites [Bmax] which persisted for at least two days following chronic clonazepam treatment. The Bmax changes observed following… Expand
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