Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study

  title={Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study},
  author={Suzann M. Babb and Lawrence L. Wald and Bruce M. Cohen and Rosamond A Villafuerte and Staci A. Gruber and Deborah A. Yurgelun-Todd and Perry F. Renshaw},
Abstract.Rationale: Phosphatidylcholine (PtdCho) in brain cell membranes decreases with age. Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Objectives: We investigated whether oral citicoline can increase PtdCho synthesis in the brains of older subjects by measuring levels of phosphorus-containing metabolites using proton-decoupled phosphorus magnetic… 

Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy

Data show that citicoline improves frontal lobe bioenergetics and alters phospholipid membrane turnover and may help to mitigate cognitive declines associated with aging by increasing energy reserves and utilization, as well as increasing the amount of essential phospholIPid membrane components needed to synthesize and maintain cell membranes.

Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T.

This is the first study to report a direct effect of uridine on membrane phospholipid precursors in healthy adults using 31-phosphorus magnetic resonance spectroscopy (31) P-MRS, and appears to increase PME in healthy subjects.

Neurochemical Alterations in Methamphetamine-Dependent Patients Treated with Cytidine-5′-Diphosphate Choline: A Longitudinal Proton Magnetic Resonance Spectroscopy Study

Preliminary findings suggest that CDP-choline treatment may exert potential neuroprotective effects directly or indirectly because of reductions in drug use by the MA-dependent patients.

Tissue-specific differences in brain phosphodiesters in late-life major depression.

  • D. HarperJ. Jensen B. Forester
  • Biology
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2014

Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.

  • R. ConantA. Schauss
  • Biology
    Alternative medicine review : a journal of clinical therapeutic
  • 2004
Citicoline shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer's disease and appears useful for improving both the structural integrity and functionality of the neuronal membrane that may assist in membrane repair.

H Magnetic Resonance Spectroscopy (MRS) assessment of the effects of Eicosapentaenoic-Docosahexaenoic Acids and Choline-Inositol supplementation on Children with Attention Deficit Hyperactivity Disorder (ADHD)

A significant increase in the signal intensities of Choline-containing compounds and a significant raise in Choline/Creatine ratio after 6-month therapy on ADHDchildren, which correlate with the improvement of their capacities and abilities.

Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla.

Results support the hyperarousal hypothesis in PI based on lower phosphocreatine in gray matter in the PI group and a trend toward a negative association between polysomnographically determined wake after sleep onset and gray matter beta-nucleoside triphosphate and white matter phosphocholine in the primary insomnia group.

The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease: results from a randomized controlled trial

MRS reveals that Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease, in line with findings in preclinical studies.

CDP‐Choline as a Biological Supplement During Neurorecovery: A Focused Review

Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Dietary supplementation of citicoline for 12 wk improved overall memory performance, especially episodic memory, in healthy older males and females with AAMI, suggesting that regular consumption ofciticoline may be safe and potentially beneficial against memory loss due to aging.



Abnormal cerebral metabolism in polydrug abusers during early withdrawal: A 31P MR spectroscopy study

The data suggest that cerebral high energy phosphate and phospholipid metabolite changes result from long term drug abuse and/or withdrawal and that these changes can be detected and studied by 31P MRS.

Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.

Uptake of circulating choline into the brain decreases with age, and this change may be a contributing factor in onset in late life of neurodegenerative, particularly dementing, illnesses in which cholinergic neurons show particular susceptibility to loss.

An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy.

A reduction in precursors of membrane phospholipid are observed during the early and chronic stages of the schizophrenia illness, and breakdown products of membraneospholipids are increased at the early stage of illness before medication treatment.

Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy.

The phosphomonoester and phosphodiester findings are compatible with either premature aging or an exaggeration of normal programmed regressive events occurring in the neural systems sampled, and suggest functional hypoactivity of the dorsal prefrontal cortex.

Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain

In the four brain locations examined, no significant increases in Cho/Cr, [Cho], or in its major constituents were found in response to an oral challenge of 50 mg/kg of choline bitartrate, and Oral choline did not significantly affect human cerebral metabolism in the short term.

31P-NMR study of brain phospholipid structures in vivo.