Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study

@article{Babb2002ChronicCI,
  title={Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study},
  author={Stephanie Babb and L. Wald and Benjamin Cohen and Rosemond A. Villafuerte and Stephan Gruber and Deborah Yurgelun-Todd and Perry E Renshaw},
  journal={Psychopharmacology},
  year={2002},
  volume={161},
  pages={248-254}
}
Rationale: Phosphatidylcholine (PtdCho) in brain cell membranes decreases with age. Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Objectives: We investigated whether oral citicoline can increase PtdCho synthesis in the… CONTINUE READING