Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study

@article{Babb2002ChronicCI,
  title={Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study},
  author={Suzann M. Babb and Lawrence L. Wald and Bruce M. Cohen and Rosamond A Villafuerte and Staci A. Gruber and Deborah A. Yurgelun-Todd and Perry F. Renshaw},
  journal={Psychopharmacology},
  year={2002},
  volume={161},
  pages={248-254}
}
Abstract.Rationale: Phosphatidylcholine (PtdCho) in brain cell membranes decreases with age. Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Objectives: We investigated whether oral citicoline can increase PtdCho synthesis in the brains of older subjects by measuring levels of phosphorus-containing metabolites using proton-decoupled phosphorus magnetic… 

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