Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study

@article{Babb2002ChronicCI,
  title={Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study},
  author={Suzann M. Babb and Lawrence L. Wald and Bruce M Cohen and Rosamond A Villafuerte and Staci A. Gruber and Deborah A. Yurgelun-Todd and Perry F. Renshaw},
  journal={Psychopharmacology},
  year={2002},
  volume={161},
  pages={248-254}
}
Abstract.Rationale: Phosphatidylcholine (PtdCho) in brain cell membranes decreases with age. Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Objectives: We investigated whether oral citicoline can increase PtdCho synthesis in the brains of older subjects by measuring levels of phosphorus-containing metabolites using proton-decoupled phosphorus magnetic… Expand

Paper Mentions

Interventional Clinical Trial
The goal of the proposed clinical trial is to assess the effect of oral cytidine and omega-3 fatty acids (O3FA) on bipolar disorder symptoms. This study is a 4-month, randomized… Expand
ConditionsBipolar Disorder
InterventionDietary Supplement, Drug
Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy
TLDR
Data show that citicoline improves frontal lobe bioenergetics and alters phospholipid membrane turnover and may help to mitigate cognitive declines associated with aging by increasing energy reserves and utilization, as well as increasing the amount of essential phospholIPid membrane components needed to synthesize and maintain cell membranes. Expand
Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T.
TLDR
This is the first study to report a direct effect of uridine on membrane phospholipid precursors in healthy adults using 31-phosphorus magnetic resonance spectroscopy (31) P-MRS, and appears to increase PME in healthy subjects. Expand
Neurochemical Alterations in Methamphetamine-Dependent Patients Treated with Cytidine-5′-Diphosphate Choline: A Longitudinal Proton Magnetic Resonance Spectroscopy Study
TLDR
Preliminary findings suggest that CDP-choline treatment may exert potential neuroprotective effects directly or indirectly because of reductions in drug use by the MA-dependent patients. Expand
Tissue-specific differences in brain phosphodiesters in late-life major depression.
  • D. Harper, J. Jensen, +5 authors B. Forester
  • Psychology, Medicine
  • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2014
TLDR
The hypothesis that neurodegenerative processes occur in white matter in patients with late-life depression more than in the normal elderly population is supported. Expand
Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.
  • R. Conant, A. Schauss
  • Medicine
  • Alternative medicine review : a journal of clinical therapeutic
  • 2004
TLDR
Citicoline shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer's disease and appears useful for improving both the structural integrity and functionality of the neuronal membrane that may assist in membrane repair. Expand
H Magnetic Resonance Spectroscopy (MRS) assessment of the effects of Eicosapentaenoic-Docosahexaenoic Acids and Choline-Inositol supplementation on Children with Attention Deficit Hyperactivity Disorder (ADHD)
This study was carried out to assess the effect of Eicosapentaenoic-Docosahexaenoic Acids (EPA/DHA) and Choline Bitartrate-Inositol (CHO/INO) supplementation on ADHD-children by evaluating their MRSExpand
Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla.
TLDR
Results support the hyperarousal hypothesis in PI based on lower phosphocreatine in gray matter in the PI group and a trend toward a negative association between polysomnographically determined wake after sleep onset and gray matter beta-nucleoside triphosphate and white matter phosphocholine in the primary insomnia group. Expand
The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease: results from a randomized controlled trial
TLDR
MRS reveals that Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease, in line with findings in preclinical studies. Expand
CDP‐Choline as a Biological Supplement During Neurorecovery: A Focused Review
TLDR
The evidence in the published literature pertaining to use of CDP‐choline in rehabilitation populations is examined and the work yet to be done is considered. Expand
Citicoline: A Novel Therapeutic Agent with Neuroprotective, Neuromodulatory, and Neuroregenerative Properties
TLDR
Based on evidence from several trials and toxicological studies, citicoline is safe for use in pediatric and adult populations and well absorbed and highly bioavailable with oral dosing. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain
TLDR
The results suggest that compounds related to membrane degradation and excitatory neuro-transmission increase in Alzheimer's disease while compoundsrelated to neuronal integrity and inhibitory neurotransmission are decreased. Expand
Abnormal cerebral metabolism in polydrug abusers during early withdrawal: A 31P MR spectroscopy study
TLDR
The data suggest that cerebral high energy phosphate and phospholipid metabolite changes result from long term drug abuse and/or withdrawal and that these changes can be detected and studied by 31P MRS. Expand
Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.
TLDR
Uptake of circulating choline into the brain decreases with age, and this change may be a contributing factor in onset in late life of neurodegenerative, particularly dementing, illnesses in which cholinergic neurons show particular susceptibility to loss. Expand
Choline ingestion increases the resonance of choline-containing compounds in human brain: An in vivo proton magnetic resonance study
TLDR
This is the first study to the authors' knowledge where an oral nutrient has been shown to produce a detectable change in human brain composition in vivo. Expand
An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy.
TLDR
A reduction in precursors of membrane phospholipid are observed during the early and chronic stages of the schizophrenia illness, and breakdown products of membraneospholipids are increased at the early stage of illness before medication treatment. Expand
Cytidine diphosphate choline administration activates brain cytidine triphosphate: phosphocholine cytidylytransferase in aged rats
TLDR
The particulate fraction of total CT activity rose from 57% of total activity to more than 65% after 2 months of treatment, which may explain the long-term repairing effects of CDP-choline on damaged membranes of aged animals. Expand
Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy.
TLDR
The phosphomonoester and phosphodiester findings are compatible with either premature aging or an exaggeration of normal programmed regressive events occurring in the neural systems sampled, and suggest functional hypoactivity of the dorsal prefrontal cortex. Expand
Neither short-term nor long-term administration of oral choline alters metabolite concentrations in human brain
TLDR
Neither for short-term nor for long-term administration of choline do the data reveal statistically significant deviations from the basal concentrations of Cho, total N-acetyl-containing compounds, total creatine, and myo-inositol (glial marker) in any of the investigated brain regions. Expand
Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain
TLDR
In the four brain locations examined, no significant increases in Cho/Cr, [Cho], or in its major constituents were found in response to an oral challenge of 50 mg/kg of choline bitartrate, and Oral choline did not significantly affect human cerebral metabolism in the short term. Expand
31P-NMR study of brain phospholipid structures in vivo.
TLDR
A series of studies of the brain by 31P-NMR, both in vivo and in extracts, showing the information that can be derived about phospholipid structures in the brain and the presence of three major components contributing to the phosphodiester resonance: bilayerospholipids, more mobile phospholIPids, and the freely soluble cytosolic molecules glycerophosphocholine and glycersophosphoethanolamine. Expand
...
1
2
3
4
5
...