Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.

@article{Motz2010ChronicCS,
  title={Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.},
  author={Gregory T. Motz and Bryan L. Eppert and Brian W. Wortham and Robyn M. Amos-Kroohs and Jennifer L. Flury and Scott C. Wesselkamper and Michael T. Borchers},
  journal={Journal of immunology},
  year={2010},
  volume={184 8},
  pages={4460-9}
}
Chronic obstructive pulmonary disease (COPD) is a debilitating, progressive lung disease punctuated by exacerbations of symptoms. COPD exacerbations are most often associated with viral infections, and exposure to cigarette smoke (CS) followed by viral infection has been shown experimentally to enhance lung inflammation, tissue destruction, and airway fibrosis. Despite this, however, the cellular mechanisms responsible for this effect are unknown. In this study, we examined NK cell function in… CONTINUE READING

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