Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway

@inproceedings{IbarraLecue2018ChronicCP,
  title={Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway},
  author={In{\'e}s Ibarra-Lecue and Irene Mollinedo-Gajate and J Javier Meana and Luis F Callado and Rebeca Diez-Alarcia and Leyre Urig{\"u}en},
  booktitle={Neuropsychopharmacology},
  year={2018}
}
Long-term use of potent cannabis during adolescence increases the risk of developing schizophrenia later in life, but to date, the mechanisms involved remain unknown. Several findings suggest that the functional selectivity of serotonin 2A receptor (5-HT2AR) through inhibitory G-proteins is involved in the molecular mechanisms responsible for psychotic symptoms. Moreover, this receptor is dysregulated in the frontal cortex of schizophrenia patients. In this context, studies involving cannabis… CONTINUE READING
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