Chronic cannabinoid exposure during adolescence leads to long-term structural and functional changes in the prefrontal cortex.

@article{Renard2016ChronicCE,
  title={Chronic cannabinoid exposure during adolescence leads to long-term structural and functional changes in the prefrontal cortex.},
  author={Justine Renard and Tania Vitalis and Marion Rame and M O Krebs and Zsolt Lenkei and Gwena{\"e}lle Le Pen and Th{\'e}r{\`e}se M Jay},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2016},
  volume={26 1},
  pages={55-64}
}
In many species, adolescence is a critical phase in which the endocannabinoid system can regulate the maturation of important neuronal networks that underlie cognitive function. Therefore, adolescents may be more susceptible to the neural consequences of chronic cannabis abuse. We reported previously that chronically exposing adolescent rats to the synthetic cannabinoid agonist CP55,940 leads to impaired performances in adulthood i.e. long-lasting deficits in both visual and spatial short-term… CONTINUE READING
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