Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model.

@article{Li2008ChronicBN,
  title={Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model.},
  author={Wang Li and Shuangshuang Dai and Jian-zhong An and Ping Li and X Chen and Renping Xiong and P P Liu and H. Wang and Yanlin Zhao and M Y Zhu and X Liu and Peifang Zhu and J Chen and Y. Zhou},
  journal={Neuroscience},
  year={2008},
  volume={151 4},
  pages={1198-207}
}
Caffeine, the most consumed psychoactive drug and non-specific adenosine receptor antagonist, has recently been shown to exert a neuroprotective effect against brain injury in animal models of Parkinson's disease (PD) and stroke. However, the effects of caffeine on traumatic brain injury (TBI) are not known. In this study, we investigated the effects of acute and chronic caffeine treatment on brain injury in a cortical-impact model of TBI in mice. Following TBI, neurological deficits, cerebral… CONTINUE READING

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