Chronic but not acute foot-shock stress leads to temporary suppression of cell proliferation in rat hippocampus.

@article{Dagyte2009ChronicBN,
  title={Chronic but not acute foot-shock stress leads to temporary suppression of cell proliferation in rat hippocampus.},
  author={Girstaute Dagyte and Eddy A. van der Zee and Folkert Postema and Paul G. M. Luiten and Johan A. den Boer and Andrea Trentani and Peter Meerlo},
  journal={Neuroscience},
  year={2009},
  volume={162 4},
  pages={904-13}
}
Stressful experiences, especially when prolonged and severe are associated with psychopathology and impaired neuronal plasticity. Among other effects on the brain, stress has been shown to negatively regulate hippocampal neurogenesis, and this effect is considered to be exerted via glucocorticoids. Here, we sought to determine the temporal dynamics of changes in hippocampal neurogenesis after acute and chronic exposure to foot-shock stress. Rats subjected to a foot-shock procedure showed strong… CONTINUE READING
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