Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells.

@article{Shah2006ChronicBN,
  title={Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells.},
  author={Syed Ghazanfar Ali Shah and Nasir Mahmud and Mohamed Mftah and Helen M. Roche and Dermot Kelleher},
  journal={European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation},
  year={2006},
  volume={15 2},
  pages={125-33}
}
Conjugated linoleic acid (CLA) has anti-carcinogenic effects in a variety of cancers including colon cancer. Secondary bile acids on the other hand are known as tumour promoters in colon cancer with effects on protein kinase C (PKC) and nuclear factor kappa B (NF-kappaB) signalling pathways. The aim of this study was to examine acute and chronic, isomer-specific effects of CLA on bile salt-induced PKC and NF-kappaB signal transduction in human colon cancer cells. HCT116 cells were treated with… CONTINUE READING