Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment

@article{Cechetti2012ChronicBH,
  title={Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment},
  author={Fernanda Cechetti and Aline de Souza Pagnussat and Paulo Valdeci Worm and Viviane Rostirolla Elsner and Juliana Ben and Marcelo Siveira da Costa and R{\'e}gis Gemerasca Mestriner and Simone Nardin Weis and Carlos Alexandre Netto},
  journal={Brain Research Bulletin},
  year={2012},
  volume={87},
  pages={109-116}
}
Reduction of cerebral blood flow is an important risk factor for dementia states and other brain dysfunctions. In present study, the effects of permanent occlusion of common carotid arteries (2VO), a well established experimental model of brain ischemia, on memory function were investigated, as assessed by reference and working spatial memory protocols and the object recognition task; cell damage to the hippocampus, as measured through changes in immunoreactivity for GFAP and the neuronal… CONTINUE READING

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