Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity.

@article{Haarst1996ChronicBG,
  title={Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity.},
  author={Aernout D van Haarst and Melly S. Oitzl and J O Workel and Edo Ronald de Kloet},
  journal={Endocrinology},
  year={1996},
  volume={137 11},
  pages={4935-43}
}
This study examined the hypothesis that experimentally induced corticosteroid resistance in the brain would lead to adaptations in the activity of the hypothalamic-pituitary-adrenal (HPA) axis similar to the endocrine features of the endogenous resistance accompanying the pathogenesis of depression. For this purpose, the glucocorticoid antagonist RU 38486 (aGC) was infused intracerebroventricularly (i.c.v.) (100 ng/h) via Alzet minipumps for several days. During this chronic receptor blockade… CONTINUE READING