Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam.

@article{Byrnes1993ChronicBA,
  title={Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam.},
  author={John J. Byrnes and L. G. Miller and David J Greenblatt and Richard I. Shader},
  journal={Psychopharmacology},
  year={1993},
  volume={111 1},
  pages={91-5}
}
Tolerance to the sedative and anticonvulsant effects of benzodiazepines has been reported, but cross-tolerance among benzodiazepines is poorly characterized. To evaluate cross-tolerance between lorazepam and alprazolam in a reliable anticonvulsant pharmacodynamic model, we treated mice with either drug for 14 days, and with the two drugs sequentially for 7… CONTINUE READING