Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome.

@article{Torrelo2010ChronicAN,
  title={Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome.},
  author={Antonio Torrelo and Sapna Patel and Isabel Colmenero and Dolores Gurbindo and Francisco Lend{\'i}nez and Angela Hern{\'a}ndez and Juan Carlos L{\'o}pez-Robledillo and Ali Dadban and Luis Requena and Amy Paller},
  journal={Journal of the American Academy of Dermatology},
  year={2010},
  volume={62 3},
  pages={489-95}
}
Several syndromes manifest as recurrent daily fevers, skin lesions, and multisystem inflammation. We describe 4 patients with early-onset recurrent fevers, annular violaceous plaques, persistent violaceous eyelid swelling, low weight and height, lipodystrophy, hepatomegaly, and a range of visceral inflammatory manifestations. Laboratory abnormalities included chronic anemia, elevated acute-phase reactants, and raised liver enzymes. Histopathologic examination of lesional skin showed atypical… CONTINUE READING