Chronic atrial fibrillation alters the functional properties of If in the human atrium.

@article{Stillitano2013ChronicAF,
  title={Chronic atrial fibrillation alters the functional properties of If in the human atrium.},
  author={Francesca Stillitano and Giuseppe Lonardo and Gabriele Giunti and Martina Del Lungo and Raffaele Coppini and Valentina Spinelli and Laura Sartiani and Corrado Poggesi and Alessandro Mugelli and Elisabetta Cerbai},
  journal={Journal of cardiovascular electrophysiology},
  year={2013},
  volume={24 12},
  pages={
          1391-400
        }
}
INTRODUCTION Despite the evidence that the hyperpolarization-activated current (If) is highly modulated in human cardiomyopathies, no definite data exist in chronic atrial fibrillation (cAF). We investigated the expression, function, and modulation of If in human cAF. METHODS AND RESULTS Right atrial samples were obtained from sinus rhythm (SR, n = 49) or cAF (duration >1 year, n = 31) patients undergoing corrective cardiac surgery. Among f-channel isoforms expressed in the human atrium (HCN1… CONTINUE READING
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