Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice

@article{Finamor2017ChronicAI,
  title={Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice},
  author={Isabela Finamor and Salvador P{\'e}rez and Caroline A. Bressan and Carlos E. Brenner and Sergio Rius-P{\'e}rez and Patricia C. Brittes and Gabriele Cheiran and Maria Isabel Antunes Rocha and Marcelo L da Veiga and Juan Sastre and Maria Am{\'a}lia Pavanato},
  journal={Redox Biology},
  year={2017},
  volume={11},
  pages={701 - 707}
}
  • Isabela Finamor, Salvador Pérez, +8 authors Maria Amália Pavanato
  • Published 2017
  • Medicine, Chemistry
  • Redox Biology
  • No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. Our aim was to study the effect of chronic administration of aspartame on glutathione redox status and on the trans-sulphuration pathway in mouse liver. Mice were divided into three groups: control; treated daily with… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 16 CITATIONS

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 38 REFERENCES

    Effect of long term intake of aspartame on antioxidant defense status in liver.