Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?

  title={Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?},
  author={J. Cosyns and J. Dehoux and Y. Guiot and R. Goebbels and A. Robert and A. Bernard and C. van Ypersele de Strihou},
  journal={Kidney international},
  volume={59 6},
  • J. Cosyns, J. Dehoux, +4 authors C. van Ypersele de Strihou
  • Published 2001
  • Medicine
  • Kidney international
  • BACKGROUND Chinese herbs nephropathy (CHN) is a new type of subacute interstitial nephritis that is attributed to aristolochic acid (AA), which inadvertently has been included in slimming pills. The contribution of other simultaneously prescribed drugs remains disputed. In the present study, the effects of a chronic intake of AA given as a single drug was evaluated through renal histology and function in rabbits. METHODS Female New Zealand White rabbits were injected intraperitoneally with… CONTINUE READING
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