Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative stress markers in the kidney in Wistar rats.

@article{Nishi2010ChronicAT,
  title={Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative stress markers in the kidney in Wistar rats.},
  author={Erika Emy Nishi and Elizabeth Barbosa de Oliveira-Sales and C{\'a}ssia M de Toledo Bergamaschi and Thais Galv{\~a}o C{\'e}sar Oliveira and Mirian Aparecida Boim and Ruy Ribeiro de Campos},
  journal={American journal of hypertension},
  year={2010},
  volume={23 5},
  pages={
          473-80
        }
}
BACKGROUND Sympathetic vasomotor hyperactivity and baroreflex dysfunction are involved in the development and maintenance of renovascular arterial hypertension. We hypothesized that angiotensin (Ang) II-dependent oxidative stress contributes to the pathophysiology of the two-kidney, one-clip (2K-1C) model. METHODS The mean arterial pressure (MAP), baroreflex, and renal sympathetic nerve activity (rSNA) were evaluated after chronic administration of an antioxidant, vitamin C (vitC 150 mg/kg… CONTINUE READING
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