Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion.

@article{Bucks2009ChronicAS,
  title={Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion.},
  author={Christine M. Bucks and Jillian A. Norton and Alina C Boesteanu and Yvonne M Mueller and Peter D Katsikis},
  journal={Journal of immunology},
  year={2009},
  volume={182 11},
  pages={6697-708}
}
The failure of CD8(+) T cells to respond to chronic infection has been termed "exhaustion" and describes the condition in which CD8(+) T cells exhibit reduced differentiation, proliferation, and effector function. CD8(+) T cell exhaustion has been extensively studied in the murine model of chronic infection, lymphocytic choriomeningitis virus (LCMV). Although LCMV-based studies have yielded many interesting findings, they have not allowed for discrimination between the roles of cytokine- and Ag… CONTINUE READING
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