Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus.

@article{MartnezTurrillas2002ChronicAT,
  title={Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus.},
  author={Rebeca Mart{\'i}nez-Turrillas and Diana Frechilla and J R Send{\'o}n del R{\'i}o},
  journal={Neuropharmacology},
  year={2002},
  volume={43 8},
  pages={1230-7}
}
It has been proposed that potentiation of AMPA receptor (AMPAR) function may be useful in the treatment of depression. Here we studied the acute and chronic effect of the antidepressants desipramine and paroxetine, which differentially affect monoamine reuptake, on the expression of the AMPAR subunits GluR1 and GluR2/3, analyzed by Western blot, both in total and in membrane-enriched extracts from rat hippocampus. Acute antidepressant treatment did not produce any change in the expression of… CONTINUE READING