Chronic antidepressant administration fails to attenuate apomorphine-induced decreases in rat striatal dopamine metabolites.


The responsiveness of the rat striatal dopamine (DA) receptor system to apomorphine (APO) was assessed after 10 days of antidepressant administration. Desipramine (DMI), dothiepin (DOTH), iprindole (IPR) and nomifensine (NOM) were administered intra-peritoneally, twice daily, to rats for 10 days and 42 h after the last drug dose, animals were injected with… (More)


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