Chronic alcohol intake does not change thiopental anesthetic requirement, pharmacokinetics, or pharmacodynamics.

@article{Swerdlow1990ChronicAI,
  title={Chronic alcohol intake does not change thiopental anesthetic requirement, pharmacokinetics, or pharmacodynamics.},
  author={B N Swerdlow and F O Holley and Pierre O. Maitre and Donald R. Stanski},
  journal={Anesthesiology},
  year={1990},
  volume={72 3},
  pages={455-61}
}
The anesthetic requirements of chronic alcoholics for induction of anesthesia with thiopental were investigated using an electroencephalographic (EEG) measure of thiopental's CNS drug effect and pharmacodynamic modeling to relate thiopental serum concentrations to drug effect. Eleven patients with a history of excessive alcohol intake were studied from an inpatient alcohol rehabilitation program and compared with nine control patients or volunteers who were social drinkers. The alcoholic… CONTINUE READING

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