Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo.

@article{Mannaerts2010ChronicAO,
  title={Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo.},
  author={Inge Mannaerts and Nele R Nuytten and Vera Rogiers and Karin Vanderkerken and Leo A van Grunsven and A. A. J. Geerts},
  journal={Hepatology},
  year={2010},
  volume={51 2},
  pages={603-14}
}
UNLABELLED Hepatic stellate cell (HSC) activation is a pivotal step in the pathogenesis of liver fibrosis. The clarification of this transdifferentiation process is therefore important for the development of effective therapies for fibrosis. We analyzed the effect of a histone deacetylase inhibitor, valproic acid (VPA), on mouse HSC transdifferentiation in vitro and in vivo. The exposure of freshly isolated mouse HSCs to 2.5 mM VPA led to increased histone H4 acetylation and inhibited cell… CONTINUE READING

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