Chronic administration of typical, but not atypical neuroleptics induce persisting alterations in rest-activity cycles in rats.

@article{Ellison1990ChronicAO,
  title={Chronic administration of typical, but not atypical neuroleptics induce persisting alterations in rest-activity cycles in rats.},
  author={Gaylord Ellison and Ronald Eugene See},
  journal={Pharmacology, biochemistry, and behavior},
  year={1990},
  volume={36 4},
  pages={807-11}
}
The behavior of rats administered chronic neuroleptics was observed using an extremely sensitive, computerized device which detected any cage movements, thereby continuously monitoring even very small levels of activity. In the first experiment, it was found that normal rats have a strong rest-activity rhythm with a cycle length of 60-70 min, whereas rats which have been chronically administered either haloperidol (HAL) or fluphenazine (FLU) decanoate for 20 months show a distinct lengthening… CONTINUE READING