Corpus ID: 57269999

Chronic administration of phytoestrogen "daidzein" to ameliorate mean arterial pressure and vascular function in N-G-nitro-L-arginine methyl ester hypertensive rats.

  title={Chronic administration of phytoestrogen "daidzein" to ameliorate mean arterial pressure and vascular function in N-G-nitro-L-arginine methyl ester hypertensive rats.},
  author={Shahid Prawez and Azad Ahmad Ahanger and Thakur Uttam Singh and Santosh Kumar Mishra and Souvendra Nath Sarkar and Shafiqur Rahman},
  journal={Veterinarski Arhiv},
The 'silent killer', hypertension, leads to heart disease, stroke, kidney failure and premature death. The phytoestrogen daidzein has been associated with vaso-protective action similar to oestrogen, with minimal side effects. To explore the vaso-protective activity of daidzein and also its effect on mean arterial pressure (MAP), daidzein was chronically administered in N-G-nitro-L-arginine methyl ester (L-NAME)-hypertensive male Wistar rats for 6 weeks. The male Wistar rats were divided into… Expand
2 Citations
The Antihypertensive Potential of Flavonoids from Chinese Herbal Medicine: A Review.
  • Yi Cao, Long Xie, +6 authors Xiaofang Li
  • Medicine
  • Pharmacological research
  • 2021
Despite the substantial evidence of the potential for flavonoids in the control of hypertension, it is not sufficient to support the clinical application of flavonoid as an adjuvant or core drug, and the aspects that should be strengthened in future researches are highlighted. Expand
The Vascular Effects of Isolated Isoflavones—A Focus on the Determinants of Blood Pressure Regulation
The main actions of isolated isoflavones on the vasculature are reviewed, with particular focus given to their effect on the determinants of blood pressure regulation. Expand


Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats.
It is indicated that soy isoflavone has an antihypertensive effect, possibly through the amelioration of oxidative stress, and the augmentation of NO production, in SHR. Expand
Chronic treatment of male rats with daidzein and 17β‐oestradiol induces the contribution of EDHF to endothelium‐dependent relaxation
It is demonstrated that endothelium‐dependent relaxation of male rat aorta is normally entirely mediated by NO, whereas treatment with daidzein or 17β‐oestradiol stimulates a contribution from a non‐NO, nonprostaglandin factor acting through the opening of SKCa and IKCa channels, and involving activation of Na/K‐ATPase, KIR and CYP450 epoxygenase. Expand
Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats.
Genistein supplementation enhanced the circulating levels of the phytoestrogen and affected NOS activity and endothelial dysfunction to the same extent and 17 beta-estradiol show overlapping effects on experimental endothelial function. Expand
Effects of daidzein sulfates on blood pressure and artery of rats.
The results suggest that daidzein sulfates possess significant hypotensive and vasodilator effects which mainly derive from artery smooth muscle cells by inhibiting the receptor-mediated Ca(2+)-influx. Expand
Daidzein and 17β-Estradiol Enhance Nitric Oxide Synthase Activity Associated with an Increase in Calmodulin and a Decrease in Caveolin-1
Daidzein or 17β-estradiol treatment selectively enhances endothelium-dependent relaxation in male rats through an increase in eNOS activity, associated with a decreased expression of caveolin-1 and an increased expression of calmodulin in endothelial cells. Expand
L-NAME hypertension alters endothelial and smooth muscle function in rat aorta. Prevention by trandolapril and verapamil.
The effects of oral treatment with N omega-nitro-L-arginine methyl ester for 6 weeks on vascular reactivity of the aorta in Wistar-Kyoto rats with chronic administration of nitric oxide inhibitors are investigated. Expand
Endothelium-dependent relaxation of rat aorta and main pulmonary artery by the phytoestrogens genistein and daidzein.
The results show that the relaxation of these rat arteries by concentrations of genistein and daidzein which overlap those present in human plasma after ingestion of soybean-containing meals is largely endothelium dependent. Expand
Soy Isoflavones Improve Endothelial Function in Spontaneously Hypertensive Rats in an Estrogen-Independent Manner: Role of Nitric-Oxide Synthase, Superoxide, and Cyclooxygenase Metabolites
The isoflavones genistein and daidzein and 17β-estradiol restore endothelial function in male SHR through estrogen receptor-independent mechanisms. Expand
Effect of 17β-estradiol in hypercholesterolemic rabbits with severe endothelial dysfunction.
It is demonstrated that estrogen treatment may exert protection against atherosclerosis even in patients with severe endothelial dysfunction, and 17β-Estradiol treatment significantly increased EDNO production under these conditions as well. Expand
Role of Protein Kinase G in Nitric Oxide Deficiency-induced Supersensitivity to Nitrovasodilator in Rat Pulmonary Artery
The increased sensitivity of G-kinase to cGMP observed in the present study suggests a novel mechanism of supersensitivity in vascular smooth muscle to nitrovasodilators in acute NO deficiency. Expand