Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism.

@article{Raposinho2001ChronicAO,
  title={Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism.},
  author={Paula D. Raposinho and Dominique D. Pierroz and Pierre Broqua and Richard B. White and Thierry Pedrazzini and Michel Lucien Aubert},
  journal={Molecular and cellular endocrinology},
  year={2001},
  volume={185 1-2},
  pages={195-204}
}
Neuropeptide Y (NPY) is involved in the central regulation of appetite, sexual behavior, and reproductive function. We have previously shown that chronic infusion of NPY into the lateral ventricle of normal rats produced an obesity syndrome characterized by hyperphagia, hyperinsulinism and collapse of reproductive function. We further demonstrated that acute inhibition of LH secretion in castrated rats was preferentially mediated by the NPY receptor subtype 5 (Y(5)). In the present study, the… CONTINUE READING
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