Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus

@article{Fortunato2010ChronicAO,
  title={Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus},
  author={Juc{\'e}lia Jeremias Fortunato and Gislaine Zilli R{\'e}us and Tamires R. Kirsch and Roberto Buss Stringari and Gabriel Rodrigo Fries and Fl{\'a}vio Kapczinski and Jaime Eduardo Cecilio Hallak and Ant{\^o}nio Waldo Zuardi and Jos{\'e} Alexandre S. Crippa and Jo{\~a}o Quevedo},
  journal={Journal of Neural Transmission},
  year={2010},
  volume={117},
  pages={1131-1137}
}
A growing body of evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with harmine and imipramine in rats. To this aim, rats were treated for 14 days once a day with harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) and then subjected to the forced swimming and open-field tests. Harmine and imipramine, at all… CONTINUE READING

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