Chronic administration of corticosterone impairs LH signal transduction and steroidogenesis in rat Leydig cells.

@article{Sankar2000ChronicAO,
  title={Chronic administration of corticosterone impairs LH signal transduction and steroidogenesis in rat Leydig cells.},
  author={B R Sankar and R R M Maran and Ramadoss Sivakumar and Pera Govindarajulu and Karundevi Balasubramanian},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2000},
  volume={72 3-4},
  pages={155-62}
}
The mechanism involved in the inhibitory actions of chronic corticosterone treatment on Leydig cell steroidogenesis was studied in adult Wistar rats. Rats were treated with corticosterone-21-acetate (2 mg/100 g body weight, i.m., twice daily) for 15 days and another set of rats was treated with corticosterone plus ovine luteinizing hormone (oLH) (100 microg/kg body weight, s.c., daily) for 15 days. Chronic treatment with corticosterone increased serum corticosterone but decreased serum LH… CONTINUE READING