Chronic administration of cannabidiol to healthy volunteers and epileptic patients.

@article{Cunha1980ChronicAO,
  title={Chronic administration of cannabidiol to healthy volunteers and epileptic patients.},
  author={Jos{\'e} Eduardo Monteiro Cunha and Elisaldo Luiz de Ara{\'u}jo Carlini and Arturo Pereira and Osvaldo Luiz Ramos and Cristi{\'a}n Pimentel and Rosemarie Gagliardi and Wilson Luiz Sanvito and N M Lander and Raphael Mechoulam},
  journal={Pharmacology},
  year={1980},
  volume={21 3},
  pages={175-85}
}
In phase 1 of the study, 3 mg/kg daily of cannabidiol (CBD) was given for 30 days to 8 health human volunteers. Another 8 volunteers received the same number of identical capsules containing glucose as placebo in a double-blind setting. Neurological and physical examinations, blood and urine analysis, ECG and EEG were performed at weekly intervals. In phase 2 of the study, 15 patients suffering from secondary generalized epilepsy with temporal focus were randomly divided into two groups. Each… CONTINUE READING
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