Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury

  title={Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury},
  author={Anthony E. Kline and Ann N. Hoffman and Jeffrey P. Cheng and R. D. Zafonte and Jaime L. Massucci},
  journal={Neuroscience Letters},
Antipsychotics are often administered to traumatic brain injured (TBI) patients as a means of controlling agitation, albeit the rehabilitative consequences of this intervention are not well known. Hence, the goal of this study was to evaluate the effects of risperidone (RISP) and haloperidol (HAL) on behavioral outcome after experimental TBI. Anesthetized rats received either a cortical impact or sham injury and then were randomly assigned to five TBI (RISP 0.045mg/kg, RISP 0.45mg/kg, RISP 4… CONTINUE READING
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