Chronic administration of angiotensin-(1-7) attenuates pressure-overload left ventricular hypertrophy and fibrosis in rats.

@article{Wang2005ChronicAO,
  title={Chronic administration of angiotensin-(1-7) attenuates pressure-overload left ventricular hypertrophy and fibrosis in rats.},
  author={Lijun Wang and Jian-gui He and Hong Ma and Yi-ming Cai and Xin-Xue Liao and Wu-tao Zeng and Jun Liu and Lichun Wang},
  journal={Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA},
  year={2005},
  volume={25 5},
  pages={481-7}
}
OBJECTIVE To test the hypothesis that chronic administration of angiotensin-(1-7) [Ang-(1-7)] attenuates cardiac hypertrophy in rats in vivo. METHODS Coarctation of the suprarenal abdominal aorta was performed in 41 8-week-old male Sprague Dawley rats. Twenty-four hours after the operation, osmotic minipumps were surgically implanted subcutaneously in the rats, which were randomly divided into 3 groups, including a sham-operation group (n=15) receiving infusion with normal saline, a… CONTINUE READING

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