Chronic administration of Sildenafil improves markers of endothelial function in men with Type 2 diabetes.

@article{Aversa2008ChronicAO,
  title={Chronic administration of Sildenafil improves markers of endothelial function in men with Type 2 diabetes.},
  author={Antonio Aversa and Cristiana Vitale and Maurzio Volterrani and Alba Fabbri and Giovanni Spera and Massimo Fini and Giuseppe M. C. Rosano},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2008},
  volume={25 1},
  pages={37-44}
}
OBJECTIVE Diabetic patients have a reduced endothelial response to phosphodiesterase-5 inhibitors. The aim of this study was to determine the effects of chronic therapy with sildenafil on endothelial function in patients with Type 2 diabetes mellitus (DM2). METHODS In a double-blind, placebo-controlled parallel design, 20 patients without erectile dysfunction randomly received a loading dose of sildenafil (100 mg) for 3 days, followed by either sildenafil 25 mg three times a day (t.d.s.) for… CONTINUE READING