Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

@article{Kukar2006ChronicAO,
  title={Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice},
  author={Thomas L Kukar and Sonya L Prescott and Jason L Eriksen and Vallie M Holloway and Michael P Murphy and Edward H. Koo and Todd E Golde and Michelle M Nicolle},
  journal={BMC Neuroscience},
  year={2006},
  volume={8},
  pages={54 - 54}
}
Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD). We and others have shown that certain NSAIDs reduce secretion of Aβ42 in cell culture and animal models, and that the effect of NSAIDs on Aβ42 is independent of the inhibition of cyclooxygenase by these compounds. Since Aβ42 is hypothesized to be the initiating pathologic molecule in AD, the ability of these compounds to lower Aβ42 selectively may be associated… CONTINUE READING