Chronic administration of NMDA antagonists induces D2 receptor synthesis in rat striatum.

@article{Micheletti1992ChronicAO,
  title={Chronic administration of NMDA antagonists induces D2 receptor synthesis in rat striatum.},
  author={Giancarlo Micheletti and B{\'e}atrice Lannes and C{\'e}line Haby and Emiliana Borrelli and Eliane Kempf and Jean Marie Warter and Jean Zwiller},
  journal={Brain research. Molecular brain research},
  year={1992},
  volume={14 4},
  pages={363-8}
}
Dopamine D2 receptor gene expression was examined in rat striatum after chronic treatment with N-methyl-D-aspartate (NMDA) receptor antagonists (ketamine at 15 mg/kg/day or MK-801 at 0.1, 0.2 and 0.4 mg/kg/day per os, for 50 days). The long-isoform mRNA, as well as the total D2 mRNA expression were induced. No change was noticed in striatal dopamine release or turnover. D2 binding studies carried out in MK-801 chronically treated (0.3 mg/kg/day per os, for 50 days) and control rats revealed an… CONTINUE READING

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