Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

@inproceedings{Ng2016ChronicAD,
  title={Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice},
  author={Roy Chun-Laam Ng and On-Yin Cheng and Min Jian and Jason Kwan and Philip Ho and Kenneth King-yip Cheng and P. K. W. Yeung and Lena Lei Zhou and Ruby Lai-chong Hoo and Sookja K Chung and Aimin Xu and Karen Siu-Ling. Lam and Koon Ho Chan},
  booktitle={Molecular Neurodegeneration},
  year={2016}
}
Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimer’s disease (AD). Increasing evidence suggests that insulin resistance plays an important role in AD pathogenesis, possibly due to abnormal GSK3β activation, causing intra- and extracellular amyloid-beta (Aβ) accumulation. Adiponectin (APN) is an adipokine with insulin-sensitizing and anti-inflammatory effects. Reduced circulatory APN level is associated with… CONTINUE READING
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Adiponectin signaling and function in insulin target tissues

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