Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.

@article{Menon2012ChronicAO,
  title={Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.},
  author={Suchithra Menon and Jessica L. Yecies and Hui Hua Zhang and Jessica J Howell and Justin W Nicholatos and Eylul Harputlugil and Roderick Terry Bronson and David J Kwiatkowski and Brendan D. Manning},
  journal={Science signaling},
  year={2012},
  volume={5 217},
  pages={ra24}
}
The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a nutrient-sensitive protein kinase that is aberrantly activated in many human cancers. Whether dysregulation of mTORC1 signaling in normal tissues increases the risk for cancer, however, is unknown. We focused on hepatocellular carcinoma, which has been linked to environmental factors that affect mTORC1 activity, including diet. Ablation of the gene encoding TSC1 (tuberous sclerosis complex 1), which as part of the TSC1-TSC2… CONTINUE READING
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