Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis.

@article{Bergeron2001ChronicAO,
  title={Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis.},
  author={R. Bergeron and J. Ren and K. S. Cadman and Irene K. Moore and P. Perret and M. Pypaert and L. Young and C. Semenkovich and G. Shulman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 6},
  pages={
          E1340-6
        }
}
  • R. Bergeron, J. Ren, +6 authors G. Shulman
  • Published 2001
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
  • The underlying mechanism by which skeletal muscle adapts to exercise training or chronic energy deprivation is largely unknown. To examine this question, rats were fed for 9 wk either with or without beta-guanadinopropionic acid (beta-GPA; 1% enriched diet), a creatine analog that is known to induce muscle adaptations similar to those induced by exercise training. Muscle phosphocreatine, ATP, and ATP/AMP ratios were all markedly decreased and led to the activation of AMP-activated protein… CONTINUE READING
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