Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis.

@article{Bergeron2001ChronicAO,
  title={Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis.},
  author={R. Bergeron and J. Ren and K. S. Cadman and Irene K. Moore and P. Perret and M. Pypaert and L. Young and C. Semenkovich and G. Shulman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 6},
  pages={
          E1340-6
        }
}
  • R. Bergeron, J. Ren, +6 authors G. Shulman
  • Published 2001
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
    • The underlying mechanism by which skeletal muscle adapts to exercise training or chronic energy deprivation is largely unknown. To examine this question, rats were fed for 9 wk either with or without beta-guanadinopropionic acid (beta-GPA; 1% enriched diet), a creatine analog that is known to induce muscle adaptations similar to those induced by exercise training. Muscle phosphocreatine, ATP, and ATP/AMP ratios were all markedly decreased and led to the activation of AMP-activated protein… CONTINUE READING
    View PDF
    498 Citations
    Highly Influential Citations
    31
    Background Citations
    226
    Methods Citations
    10
    Results Citations
    8
    498 Citations
    Citation Type

    Citation Type

    Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle.
    • E. Ojuka
    • Biology, Medicine
    • The Proceedings of the Nutrition Society
    • 2004
    • 234
    • Highly Influenced
    • PDF
    Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis
    • 412
    • PDF
    Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT 4 levels in muscle
    • 37
    • Highly Influenced
    • PDF
    Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
    • 150
    • PDF
    AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.
    • 105
    Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle.
    • 49
    • PDF
    Normal hypertrophy accompanied by phosphoryation and activation of AMP‐activated protein kinase α1 following overload in LKB1 knockout mice
    • 108
    Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles.
    • 257
    • PDF
    Exercise increases nuclear AMPK α2 in human skeletal muscle
    • 133
    • PDF
    5’ Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise
    • 78

    References

    SHOWING 1-10 OF 50 REFERENCES
    Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle.
    • 703
    • PDF
    Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport
    • 809
    • PDF
    Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain.
    • 130
    AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.
    • 353
    • PDF
    AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.
    • 935
    • PDF
    Adaptation of muscle to creatine depletion: effect on GLUT-4 glucose transporter expression.
    • 86
    Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.
    • 776
    • PDF
    Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
    • 321
    • PDF
    Respiratory Uncoupling Induces δ-Aminolevulinate Synthase Expression through a Nuclear Respiratory Factor-1-dependent Mechanism in HeLa Cells*
    • 87
    • PDF
    Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.
    • 338