Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle.

@article{Holmes1999ChronicAO,
  title={Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle.},
  author={Beverly Holmes and E J Kurth-Kraczek and William Winder},
  journal={Journal of applied physiology},
  year={1999},
  volume={87 5},
  pages={1990-5}
}
This study was designed to determine whether chronic chemical activation of AMP-activated protein kinase (AMPK) would increase glucose transporter GLUT-4 and hexokinase in muscles similarly to periodic elevation of AMPK that accompanies endurance exercise training. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), has previously been shown to be taken up by cells and phosphorylated to form a compound (5-aminoimidazole-4-carboxamide ribonucleotide) that mimics the… CONTINUE READING
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Hirshman , L . J . Goodyear , and W . W . Winder . 5 8 - AMP - activated protein kinase activation causes GLUT 4 translocation in skeletal muscle

  • J. D. McGarry, M. J. Stark
  • Diabetes
  • 1999

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