Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice

  title={Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice},
  author={O. B. Smeland and T. W. Meisingset and K. Borges and U. Sonnewald},
  journal={Neurochemistry International},
  • O. B. Smeland, T. W. Meisingset, +1 author U. Sonnewald
  • Published 2012
  • Chemistry, Medicine
  • Neurochemistry International
  • Acetyl-L-carnitine (ALCAR), the short-chain ester of carnitine, is a common dietary supplement readily available in health food stores, claimed to improve energy levels and muscle strength. ALCAR has numerous effects on brain and muscle metabolism, protects against neurotoxic insults and may be an effective treatment for certain forms of depression. However, little is known about the effect of chronic ALCAR supplementation on the brain metabolism of healthy mice. Here, we investigated ALCAR's… CONTINUE READING
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