Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice

@article{Smeland2012ChronicAA,
  title={Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice},
  author={O. B. Smeland and T. W. Meisingset and K. Borges and U. Sonnewald},
  journal={Neurochemistry International},
  year={2012},
  volume={61},
  pages={100-107}
}
  • O. B. Smeland, T. W. Meisingset, +1 author U. Sonnewald
  • Published 2012
  • Chemistry, Medicine
  • Neurochemistry International
  • Acetyl-L-carnitine (ALCAR), the short-chain ester of carnitine, is a common dietary supplement readily available in health food stores, claimed to improve energy levels and muscle strength. ALCAR has numerous effects on brain and muscle metabolism, protects against neurotoxic insults and may be an effective treatment for certain forms of depression. However, little is known about the effect of chronic ALCAR supplementation on the brain metabolism of healthy mice. Here, we investigated ALCAR's… CONTINUE READING
    50 Citations
    l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain
    • 65
    • Highly Influenced
    The neurobiology of acetyl-L-carnitine.
    • G. Traina
    • Chemistry, Medicine
    • Frontiers in bioscience
    • 2016
    • 29
    • PDF
    Acetyl-l-Carnitine Attenuates Arsenic-Induced Oxidative Stress and Hippocampal Mitochondrial Dysfunction
    • 12
    Preventive Role of L-Carnitine and Balanced Diet in Alzheimer’s Disease
    • 1
    • PDF
    Characterization of in vitro models for evaluation of molecular mechanisms involved in the action of Acetyl-L-Carnitine
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 51 REFERENCES
    Effects of acetyl-l-carnitine on regional cerebral glucose metabolism in awake rats
    • 24
    • Highly Influential
    Cerebral metabolic effects of acetyl-l-carnitine in rats during aging
    • 10
    • Highly Influential
    Acetyl-l-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain
    • 33
    • Highly Influential
    Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
    • T. Hagen, J. Liu, +5 authors B. Ames
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2002
    • 306
    • Highly Influential
    • PDF
    Acetyl-l-Carnitine Protects Against Amyloid-Beta Neurotoxicity: Roles of Oxidative Buffering and ATP Levels
    • 65
    Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?
    • 10
    Acetyl-L-carnitine treatment stimulates oxygen consumption and biosynthetic function in perfused liver of young and old rats
    • 22
    • Highly Influential
    Anti-apoptotic effect of acetyl-l-carnitine and I-carnitine in primary cultured neurons.
    • 81