• Medicine
  • Published 2018

Chronic Voluntary Exercise-Induced Bdnf and Rcan1 is Associated with Improved Cognition and Depressive Mode in Apoe-/- Mice with Obese

@inproceedings{Tsugiyasu2018ChronicVE,
  title={Chronic Voluntary Exercise-Induced Bdnf and Rcan1 is Associated with Improved Cognition and Depressive Mode in Apoe-/- Mice with Obese},
  author={K Tsugiyasu and Masayuki Mori and Yuji Kasamaki and Yasuhiro Kawasaki and Nobuo Kato},
  year={2018}
}
Background: Obesity is associated with cognitive dysfunction and dementia, as well as a reduction in brain-derived neurotrophic factor (BDNF). The calcineurin 1 regulator (RCAN1) regulates neuronal plasticity and depressivefunction by regulating BNDF. Voluntary exercise may improve this condition. Methods and findings: Voluntary exercise was loaded in apolipoprotein E (ApoE)-/- mice by a high-fat diet (HFE, n=15) over a period of three months. Nonexercising mice with a high-fat diet (HFD, n=15… CONTINUE READING

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