Chronic Unpredictable Stress Induces a Cognitive Deficit and Anxiety-Like Behavior in Rats that is Prevented by Chronic Antidepressant Drug Treatment

@article{Bondi2008ChronicUS,
  title={Chronic Unpredictable Stress Induces a Cognitive Deficit and Anxiety-Like Behavior in Rats that is Prevented by Chronic Antidepressant Drug Treatment},
  author={Corina O. Bondi and Gustavo O Bonilla Rodriguez and Georgianna G Gould and Alan Frazer and David A Morilak},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={320-331}
}
Chronic stress is a risk factor for the development of many psychopathological conditions in humans, including major depression and anxiety disorders. There is a high degree of comorbidity of depression and anxiety. Moreover, cognitive impairments associated with frontal lobe dysfunction, including deficits in cognitive set-shifting and behavioral flexibility, are increasingly recognized as major components of depression, anxiety disorders, and other stress-related psychiatric illnesses. To… CONTINUE READING
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Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats

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