Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat

@article{Banasr2007ChronicUS,
  title={Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat},
  author={Mounira Banasr and Gerald W Valentine and Xiao-yuan Li and Shannon L Gourley and Ronald S Duman},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={496-504}
}
BACKGROUND One of the most consistent morphologic findings in postmortem studies of brain tissue from depressed patients is a decrease in the number of glia in the prefrontal cortex. However, little is known about the mechanisms that contribute to this decrease in cell number. METHODS To address this question, we subjected adult rats to chronic stress, a vulnerability factor for depression, and measured cell proliferation as a potential cellular mechanism that could underlie glial reduction… CONTINUE READING
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