Chronic Treatment with Ethanolic Extract of the Leaves of Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes

@inproceedings{Akinola2010ChronicTW,
  title={Chronic Treatment with Ethanolic Extract of the Leaves of Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes},
  author={Oluwole Busayo Akinola and Ezekiel Ademola Caxton-Martins},
  year={2010}
}
Botanical drugs are complementary therapies in the management of diabetes mellitus. In this work, we studied the effects of chronic treatment of diabetic rats with A. indica (neem) on blood glucose, pancreatic islet histopathology, and oxidative status of the pancreas. Fifty-four Wistar rats (5-8 weeks old) were randomly assigned to 5 treatment groups. Hyperglycemia was induced in 34 fasted rats with a single i.p. injection of STZ (70 mg/kg bw/d). Ethanolic extract of A. indica leaves (500 mg… CONTINUE READING