Chronic Treatment with Desipramine Improves Cognitive Performance of Rats in an Attentional Set-Shifting Test

@article{Lapiz2007ChronicTW,
  title={Chronic Treatment with Desipramine Improves Cognitive Performance of Rats in an Attentional Set-Shifting Test},
  author={Maria Danet S. Lapiz and Corina O. Bondi and David A Morilak},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={1000-1010}
}
Alterations in central monoaminergic neurotransmission are important in the actions of many antidepressants. This study tested the hypothesis that tonic elevation of noradrenergic (NA) neurotransmission in medial prefrontal cortex (mPFC) by chronic treatment with the selective norepinephrine (NE) reuptake blocker desipramine (DMI) may contribute to the beneficial cognitive effects of this antidepressant drug (AD). Male Sprague–Dawley rats were treated with DMI acutely (15 mg/kg, i.p.) or… CONTINUE READING

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Highly Influential
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