Chronic Toxicity Study of Neosaxitoxin in Rats

  title={Chronic Toxicity Study of Neosaxitoxin in Rats},
  author={Ramiro J. Zepeda and Manila Candiracci and Nicolas Lobos and Sebastian Lux and Hugo F Miranda},
  booktitle={Marine drugs},
Neosaxitoxin (NeoSTX) is a specific reversible blocker of voltage gated sodium channels on excitable cells. In the last decade, it has been tested in a number of interesting clinical trials, however there is still little information available on mammalian toxicity. Rats were treated for 12 weeks with doses of 1, 3 or 6 μg/kg of subcutaneous NeoSTX. At weeks 12 and 17, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 37 references

Similar Papers

Loading similar papers…