Chronic Subordinate Colony Housing (CSC) as a Model of Chronic Psychosocial Stress in Male Rats

@inproceedings{Nyuyki2012ChronicSC,
  title={Chronic Subordinate Colony Housing (CSC) as a Model of Chronic Psychosocial Stress in Male Rats},
  author={Kewir D. Nyuyki and Daniela I. Beiderbeck and Michael P. Lukas and Inga D. Neumann and Stefan O Reber},
  booktitle={PloS one},
  year={2012}
}
Chronic subordinate colony housing (CSC) is an adequate and reliable mouse model of chronic psychosocial stress, resulting in reduced body weight gain, reduced thymus and increased adrenal weight, long-lasting anxiety-like behaviour, and spontaneous colitis. Furthermore, CSC mice show increased corticotrophin (ACTH) responsiveness to acute heterotypic stressors, suggesting a general mechanism which allows a chronically-stressed organism to adequately respond to a novel threat. Therefore, the… CONTINUE READING

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