Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat

@inproceedings{Sterrenburg2011ChronicSI,
  title={Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat},
  author={Linda Sterrenburg and Bal{\'a}zs Gaszner and Jeroen G. J. Boerrigter and Lennart Santbergen and Mattia Bramini and Evan Elliott and Alon Chen and Bernard W. M. M. Peeters and Eric W. Roubos and Tamas L Kozicz},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Although the higher prevalence of depression in women than in men is well known, the neuronal basis of this sex difference is largely elusive. METHODS Male and female rats were exposed to chronic variable mild stress (CVMS) after which immediate early gene products, corticotropin-releasing factor (CRF) mRNA and peptide, various epigenetic-associated enzymes and DNA methylation of the Crf gene were determined in the hypothalamic paraventricular nucleus (PVN), oval (BSTov) and… CONTINUE READING
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