Chronic Stress Increases Prefrontal Inhibition: A Mechanism for Stress-Induced Prefrontal Dysfunction

@article{McKlveen2016ChronicSI,
  title={Chronic Stress Increases Prefrontal Inhibition: A Mechanism for Stress-Induced Prefrontal Dysfunction},
  author={J. McKlveen and Rachel L. Morano and M. Fitzgerald and Sandra P. Zoubovsky and Sarah N. Cassella and Jessie R Scheimann and S. Ghosal and Parinaz Mahbod and B. Packard and B. Myers and M. Baccei and J. Herman},
  journal={Biological Psychiatry},
  year={2016},
  volume={80},
  pages={754-764}
}
BACKGROUND Multiple neuropsychiatric disorders, e.g., depression, are linked to imbalances in excitatory and inhibitory neurotransmission and prefrontal cortical dysfunction, and are concomitant with chronic stress. METHODS We used electrophysiologic (n = 5-6 animals, 21-25 cells/group), neuroanatomic (n = 6-8/group), and behavioral (n = 12/group) techniques to test the hypothesis that chronic stress increases inhibition of medial prefrontal cortex (mPFC) glutamatergic output neurons… Expand
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